IRORI CombiChem

Combinatorial chemistry has become a mainstay process in the early stages of small molecule drug discovery. Solid phase combinatorial chemistry has proven to be a powerful technique used to develop compound libraries of varying size, diversity, sophistication and a high degree of inherent purity. The IRORI technique of synthesizing solid phase libraries, where each unique compound in the library is synthesized in its own chemically inert tagged microreactor, has proven to be the high productivity methodology of choice for providing high quality compounds.

Libraries generated with IRORI technology can range in size from tens to tens of thousands of compounds. Systems for implementing this technology include manual scanning and cleaving stations and fully automated sorting, washing, cleaving and evaporation workstations. All systems utilize the IRORI Directed Sorting™ approach that is run via easy to use yet powerful Synthesis Manager™ Software.

Today’s combinatorial chemist can take advantage of Directed Sorting technology through the use of Irori’s automated CombiChem Synthesis Systems or by accessing Irori’s X-Kan Xpress combinatorial chemistry synthesis services. Synthesis sorting, washing, cleavage, and evaporation services are offered for customers around the world requiring fast and efficient turnarounf of solid phase libraries.

Directed Sorting is an efficient, effective, and easily implemented vehicle to execute innovative new combinatorial chemistry variants, including diversity oriented synthesis (DOS) and dynamic combinatorial chemistry methods.  Irori CombiChem Synthesis Systems takes advantage of Directed Sorting technology allowing for efficient production of many discrete compounds.

To learn more about Directed Sorting, view the interactive demonstration.